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TraubsHHNeuron.h00001 #ifndef TraubsHHNeuron_H_ 00002 #define TraubsHHNeuron_H_ 00003 00004 #include "cbneuron.h" 00005 #include "viongate.h" 00006 #include "activechannel.h" 00007 00008 class Traubs_HH_n_Gate; 00009 class Traubs_HH_K_Channel; 00010 00011 class Traubs_HH_h_Gate; 00012 class Traubs_HH_m_Gate; 00013 class Traubs_HH_Na_Channel; 00014 00016 00058 class TraubsHHNeuron : public CbNeuron { 00059 00060 // This tells CSIM that you want to be able to access this object from Matlab 00061 DO_REGISTERING 00062 00063 public: 00065 TraubsHHNeuron(void); 00067 virtual ~TraubsHHNeuron(); 00069 virtual int init(Advancable *a); 00071 virtual int updateInternal(void); 00072 00073 private: 00075 Traubs_HH_K_Channel *k; 00077 Traubs_HH_Na_Channel *na; 00079 float Vtr; 00080 00081 }; 00082 00084 00089 #define VSCALE 1000 00090 00092 #define TSCALE 1000 00093 00095 // Traubs_HH_K_Channel 00097 00099 00106 class Traubs_HH_n_Gate : public VIonGate { 00107 00108 public: 00109 00110 Traubs_HH_n_Gate(float Vtr) { 00111 k=4; this->Vtr=Vtr; 00112 } 00113 00114 double alpha(double V) { 00115 return TSCALE*( fabs(15-(V-Vtr)*VSCALE) < 1e-15 ? 00116 0.032 * 5 : 0.032*(15-(V-Vtr)*VSCALE)/(exp((15-(V-Vtr)*VSCALE)/5.0)-1.0) ); 00117 } 00118 00119 double beta(double V) { 00120 return TSCALE*(0.5*exp((10-(V-Vtr)*VSCALE)/40.0)); 00121 } 00122 00123 // This macro must be called for each new type of gate 00124 IONGATE_TABLES(Traubs_HH_n_Gate); 00125 00126 private: 00127 float Vtr; 00128 00129 }; 00130 00132 00139 class Traubs_HH_K_Channel : public ActiveChannel { 00140 00141 DO_REGISTERING 00142 00143 public: 00144 00145 Traubs_HH_K_Channel(double Gbar=0.06*1e-4, double Erev=-0.09, float Vtr = -0.063) { 00146 addGate(new Traubs_HH_n_Gate(Vtr)); 00147 this->Gbar = Gbar; 00148 this->Erev = Erev; 00149 } 00150 00151 virtual ~Traubs_HH_K_Channel(void) { 00152 for(int i=0;i<nGates;i++) 00153 delete gates[i]; 00154 } 00155 00156 }; 00157 00158 00160 // Traubs_HH_Na_Channel 00162 00163 00165 00174 class Traubs_HH_m_Gate : public VIonGate { 00175 00176 public: 00177 00178 Traubs_HH_m_Gate(float Vtr) { k=3; this->Vtr = Vtr; } 00179 00180 double alpha(double V) { return TSCALE*( fabs(13-(V-Vtr)*VSCALE)<1e-15 ? 00181 4*0.32 : (0.32*(13-(V-Vtr)*VSCALE))/(exp((13-(V-Vtr)*VSCALE)/4.0)-1.0)) ; } 00182 00183 double beta(double V) { return TSCALE*( fabs(40-(V-Vtr)*VSCALE)<1e-15 ? 00184 0.28 * 5 : (0.28*((V-Vtr)*VSCALE-40))/(exp(((V-Vtr)*VSCALE-40)/5.0)-1.0)); } 00185 00186 IONGATE_TABLES(Traubs_HH_m_Gate); 00187 00188 private: 00189 00190 float Vtr; 00191 00192 }; 00193 00195 00203 class Traubs_HH_h_Gate : public VIonGate { 00204 00205 public: 00206 Traubs_HH_h_Gate(float Vtr) { k=1; this->Vtr = Vtr; } 00207 00208 double alpha(double V) { return TSCALE*(0.128*exp((17-(V-Vtr)*VSCALE)/18.0)); } 00209 00210 double beta(double V) { return TSCALE*(4.0/(exp((40-(V-Vtr)*VSCALE)/5.0)+1)); } 00211 00212 IONGATE_TABLES(Traubs_HH_h_Gate); 00213 00214 private: 00215 float Vtr; 00216 00217 }; 00218 00220 00228 class Traubs_HH_Na_Channel : public ActiveChannel { 00229 00230 DO_REGISTERING 00231 00232 public: 00233 00234 Traubs_HH_Na_Channel(double Gbar=0.2*1e-4,double Erev=0.050, float Vtr = -0.063) { 00235 addGate(new Traubs_HH_m_Gate(Vtr)); 00236 addGate(new Traubs_HH_h_Gate(Vtr)); 00237 this->Gbar = Gbar; 00238 this->Erev = Erev; 00239 } 00240 00241 virtual ~Traubs_HH_Na_Channel(void) { 00242 for(int i=0;i<nGates;i++) 00243 delete gates[i]; 00244 } 00245 00246 }; 00247 00248 #endif /*TraubsHHNeuron_H_*/ | |||||||||||
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| (C) 2003, Thomas Natschläger | last modified 07/10/2006 |
